KMID : 0545120080180061191
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Journal of Microbiology and Biotechnology 2008 Volume.18 No. 6 p.1191 ~ p.1196
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Inhibitory Effects of Lactobacillus plantarum Lipoteichoic Acid (LTA) on Staphylococcus aureus LTA-induced Tumor Necrosis Factor-Alpha Production
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Kim Han-Geun
Lee Seung-Yeon Kim Na-Ra Ko Mi-Yeon Lee Jung-Min Yi Tae-Hoo Chung Sung-Kyun Chung Dae-Kyun
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Abstract
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Staphylococcus aureus is a common etiologic agent for Gram-positive sepsis, and its lipoteichoic acid (LTA) may be important in causing Gram-positive bacterial septic shock. Here, we demonstrate that highly purified LTA (pLTA) isolated from Lactobacillus plantarum inhibited aureus LTA (aLTA)-induced TNF-¥á production in THP- cells. Whereas pLTA scarcely induced TNF-¥á production, aLTA induced excessive TNF-¥á production. Interestingly, aLTA-induced TNF-¥á production was inhibited by pLTA pretreatment. Compared with pLTA, aLTA induced strong signal transduction through the MyD88, NF-¥êB, and MAP kinases. This signaling, however, was reduced by a pLTA pretreatment, and resulted in the inhibition of aLTA-induced TNF-¥á production. Whereas dealanylated LTAs, as well as native LTAs, contributed to TNF- induction or TNF-¥á reduction, deacylated LTAs did not, indicating that the acyl chain of LTA played an important role in the LTA-mediated immune regulation. These results suggest that pLTA may act as an antagonist for aLTA, and that an antagonistic pLTA may be a useful agent for suppressing the septic shock caused by Gram-positive bacteria.
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KEYWORD
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Lactobacillus plantarum, lipoteichoic acid, tolerance, Gram-positive sepsis
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